The histone deacetylase HDAC1 activates HIF1α/VEGFA signal pathway in colorectal cancer.

Cheng Chen,Meng Wei,Chao Wang,Danping Sun,Peng Liu,Xin Zhong,Qingsi He,Wenbin Yu

Gene（2020）

引用 17|浏览10

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摘要

•We first found that HDAC1 is higher in CRC compared to adjacent tissues.•HDAC1-mediated tumorigenesis depends on HIF1/VEGFA signaling pathway.•These findings might present new therapeutic interventions to the tumor.

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关键词

HDAC1,HIF1α,VEGFA,CRC,GAPDH,EMT

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