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Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy.

Kai Chen,Cong Chang,Zuhao Liu,Yimin Zhou,Qingni Xu,Chaohua Li,Zhijun Huang,Haixing Xu,Peihu Xu,Bo Lu

Colloids and Surfaces B: Biointerfaces（2020）

Cited 42|Views8
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Abstract
•A novel drug delivery system was designed based on hollow mesoporous silica nanoparticles.•Hyaluronic acid was served as gatekeeper as well as targeted agent.•The system could target murine mammary carcinoma (4T1) cells.•The system could combine chemotherapy and photodynamic therapy.
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Key words
Chemo-photodynamic therapy,pH-sensitive,Hollow mesoporous silica nanoparticles,Oxidized hyaluronic acid,Targeting drug deliver
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