Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy.
Colloids and Surfaces B: Biointerfaces(2020)
Abstract
•A novel drug delivery system was designed based on hollow mesoporous silica nanoparticles.•Hyaluronic acid was served as gatekeeper as well as targeted agent.•The system could target murine mammary carcinoma (4T1) cells.•The system could combine chemotherapy and photodynamic therapy.
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Key words
Chemo-photodynamic therapy,pH-sensitive,Hollow mesoporous silica nanoparticles,Oxidized hyaluronic acid,Targeting drug deliver
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