Methods for recalibrating St Luke’s cohort to Clinical Practice Research Datalink

Optimal strategies for monitoring lipid levels in patients at risk or with cardiovascular disease: a systematic review with statistical and cost-effectiveness modelling(2015)

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Abstract
ResultsThe estimated within-measurement variability from the Japanese data set was smaller than that seen in the UK data: for example, TC/HDL cholesterol parameter estimates in men were 0.43 (95% CI 0.43 to 0.44) in the Japanese data (see Table 20) and 0.62 (95% CI 0.61 to 0.62) in the UK data (see Table 23). Table 81 shows estimated variability and change parameters for men and women when the noise variable was constrained to that estimated from the St Luke’s data. The estimates of the variation in the lipid value and annual rate of change were correspondingly larger, leading to a stronger SN ratio, as shown in Table 82.
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