tuberculosis candidate vaccine, MVA85A [version 1; referees

A more effective vaccine for tuberculosis (TB) is a global publicBackground: health priority. Vaccines under development will always need evaluation in endemic settings, most of which have limited resources. Adolescents are an important target population for a new TB vaccine and for other vaccines which are relevant at school-age. However, in most endemic settings there is limited experience of trials of investigational products among adolescents, and adolescents are not routinely vaccinated. We used(MVA85A), aMethods: Modified vaccinia Ankara-expressing Ag85A well-tolerated candidate vaccine for tuberculosis, to assess the effect of infection on vaccine immunogenicity among Ugandan