Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by organelle-targeting peptides.
CHEMICAL COMMUNICATIONS(2020)
摘要
Targeting specific cellular organelles is an elusive therapeutic goal that could be achieved by manipulating nanocrystal facets. As proof of concept, different facet-engineered nanonods (high-energy (001) CdS and (001) CdSe, and low-energy (101) CdS and (110) CdSe) exploited selective binding by organelle-targeting peptides and subsequent intracellular protein sorting to inhibit specific organelles without significant cytotoxicity.
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关键词
specific cell organelles,peptides,different-faceted,organelle-targeting
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