Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications
CHEMICAL COMMUNICATIONS(2020)
Abstract
Two types of pyridoxal analogs, azido pyridoxal (PL-N-3) and carboxyl pyridoxal (PL-COOH), were developed as novel bifunctional bioorthogonal molecules. These molecules showed fast imine formation with hydrazinyl groups and stable covalent linkagesviaazido/carboxyl groups, and thus were of great use for site-specific peptide and protein modifications.
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