Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study

•Triple therapy with steroids, vitamin C and thiamine has been recently proposed as safe and beneficial in sepsis.•Evidence based guidelines suggest low dose steroids in patients with septic shock and poor responsive to vasopressors.•In refractory septic shock the use of triple therapy seems to improve clinical outcome rather than steroids alone.