An 81 base-pair deletion in SARS-CoV-2 ORF7a identified from sentinel surveillance in Arizona (Jan-Mar 2020).

LaRinda A Holland,Emily A Kaelin,Rabia Maqsood, Bereket Estifanos,Lily I Wu,Arvind Varsani,Rolf U Halden,Brenda G Hogue,Matthew Scotch,Efrem S Lim

medRxiv : the preprint server for health sciences（2020）

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摘要

On January 26 2020, the first Coronavirus Disease 2019 (COVID-19) case was reported in Arizona of an individual with travel history (3rd case in the US). Here, we report on early SARS-CoV-2 sentinel surveillance in Tempe, Arizona. Genomic characterization identified an isolate encoding a 27 amino acid in-frame deletion in accessory protein ORF7a, the ortholog of SARS-CoV immune antagonist ORF7a/X4 .

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sentinel surveillance,base-pair,sars-cov,jan-mar

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