Inducing inflammatory response in RAW264.7 and NK-92 cells by an arabinogalactan isolated from Ferula gummosa via NF-κB and MAPK signaling pathways.

Mehdi Tabarsa,Elham Hashem Dabaghian,SangGuan You,Khamphone Yelithao,Subramanian Palanisamy,Narayanasamy Marimuthu Prabhu,Changsheng Li

Carbohydrate Polymers（2020）

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摘要

•An arabinogalactan (FGP) was isolated from Ferula gummosa.•FGP possessed a backbone of →6)-β-Galp-1→ residues with branches at C-3.•FGP stimulated RAW264.7 and NK-92 cells to release proinflammatory mediators.•Activation of RAW264.7 and NK-92 cells was via NF-κB and MAPKs pathways.

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关键词

Arabinogalactan,Stimulation,Macrophages,Natural killer cells,Signaling pathways

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