Reliable screening and classification of phosphodiesterase type 5 inhibitors in dietary supplements using gas chromatography / mass spectrometry combined with specific common ions.

•Development of a GC–MS method to screen 53 PDE-5i drugs in dietary supplements.•Microscale sample preparation combined with simple LLE and trimethylsilylation.•First description of characteristic common EI fragment ions of PDE-5i TMS derivatives.•Construction of ECICs and discriminant analysis (DA) based on specific common ions.•Reliable screening and classification of PDE-5i in supplements using ECICs and DA.