Clinical value of full-length tryptophanyl-tRNA synthetase for sepsis detection in critically ill patients-A retrospective clinical assessment.

•Sepsis is a major clinical challenge in critically ill patients, involving high mortality.•A biomarker is needed for the detection of sepsis to reflect the infection-related immune response.•Full-length tryptophanyl-tRNA synthetase (WRS) secreted early in sepsis may be useful for the early detection of sepsis.•WRS is an accurate predictive indicator of mortality in critically ill patients with sepsis.