IL-21 and IL-5 coordinately induce surface IgA + cells.

Masaaki Hashiguchi,Yuji Kashiwakura,Yumiko Kanno,Hidefumi Kojima,Tetsuji Kobata

Immunology Letters（2020）

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摘要

•Retinoic acid and TGF-β1 is enough for IgA secretion but not for surface IgA in vitro.•The addition of rIL-5 and rIL-21 coordinately induce IgA+ cells in vitro.•IL-21R or IL-5R blockade in vivo led to lower frequencies of IgA+ in Peyer’s patches.

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关键词

APRIL,B6,BAFF,CFSE,GC,h,Ig,ip,LN,LPS,OVA,PCR,PP,q,r,RA,RT,TCR,TGF,TD,TNP,Tfh,TI,TNF

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