Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish.

Jiawei Li,Ting Dong,Tharushi P Keerthisinghe,Hao Chen,Ming Li, Wenqing Chu,Jingfeng Yang,Zongfu Hu,Shane Allen Snyder, Wu Dong,Mingliang Fang

Journal of Hazardous Materials（2020）

引用 33|浏览16

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摘要

•OTC affects the thyroid hormone homeostasis, especially the active T3.•OTC affects the 5-HT synthesis in the brain by reducing TPH2 expression.•OTC alters gut microbial diversity with a sharp increase of Fusobacteria and Proteobacteria and decrease of Actinobacteria.

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关键词

Oxytetracycline,Zebrafish,Thyroid hormone,Serotonin,Gut microbiome

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