Development Of Hydrophilic Polyacrylamide Gel-Based Condensing Reagents Comprised Of Chlorotriazine

Hydrophilic polyacrylamide gel-based triazine-type condensing reagents, PAG-Trz-Cl, have been developed. PAG-Trz- Cls were synthesized using a chlorotriazine with an acrylamide moiety, acrylamide, and N, N'-methylenebisacrylamide via both precipitation and solution polymerization. Because PAG-Trz-Cls adequately swell in aqueous media, the amidation between polar carboxylic acids and amines afforded the corresponding amides in good yields.