Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol.

Luisa Möhle, Barbora Schwarzová,Markus Krohn,Sven Marcel Stefan,Jens Pahnke

Journal of Pharmacological and Toxicological Methods（2020）

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摘要

Our approach is biologically more relevant than cell-free assays. The continuous detection of kinetics allows for a more precise quantification compared with assays with single end-point measurements.

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关键词

ABCC1,ABC transporter activity,Blood-brain barrier,Cell-based assay,Drug screening,Methods,Multidrug resistance-associated protein 1 (MRP1),Plant extract testing

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