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Charge-reversible Lipid Derivative: A Novel Type of pH-responsive Lipid for Nanoparticle-mediated siRNA Delivery.

Yusuke Hirai, Ryoko Saeki,Furan Song,Hiroyuki Koide, Naofumi Fukata,Koji Tomita,Noriyuki Maeda,Naoto Oku,Tomohiro Asai

International Journal of Pharmaceutics（2020）

Cited 19|Views59
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Abstract
•A charge-reversible lipid derivative is a novel type of pH-responsive lipid.•A charge-reversible lipid nanoparticle (LNP) is useful for siRNA delivery.•Apolipoprotein E3 enhances uptake of charge-reversible LNPs into cancer cells.
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Key words
Charge-reversible lipid derivative,Small interfering RNA,Lipid nanoparticle,Apolipoprotein E3
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