Ectopic over expression of kiss1 may compensate for the loss of kiss2.

Etzion Talya,Zmora Nilli, Zohar Yonatan,Levavi-Sivan Berta,Golan Matan,Gothilf Yoav

General and Comparative Endocrinology（2020）

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摘要

•kiss1 and kiss2 knockout zebrafish exhibited normal reproductive competence.•Expression of several reproductive-related neuropeptides increased in kiss2 KO fish.•Ectopic kiss1 expression occurs in the brain of kiss2 KO fish.•Kiss1 may compensate for the loss Kiss2.

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关键词

CRISPR,dpf,fshβ,GnRH,HPG,IHC,ISH,KISS,kiss1−/−,kiss2−/−,KISSR,KO,lhβ,NKB,RTqPCR,sgRNA,tac,TALEN,T7EI

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