Cognitive and Clinical Predictors of Prefrontal Cortical Thickness Change Following First-Episode of Psychosis.

Giulia Tronchin,Theophilus N Akudjedu,Joanne Pm Kenney,Shane McInerney,Cathy Scanlon,John McFarland,Peter McCarthy,Dara M Cannon,Brian Hallahan,Colm McDonald

Psychiatry Research: Neuroimaging（2020）

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摘要

•Longitudinal pipeline of Freesurfer was used to parcellate prefrontal cortex•FEP at baseline showed specific cognitive deficits compared with controls•Prefrontal thinning over time was predicted by impaired working memory at baseline•Emotional intelligence deficit at baseline predicts orbitofrontal thinning over time•Negative symptoms worsening occurs with prefrontal thinning as illness progresses

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关键词

First-episode psychosis,Cognitive impairment,Magnetic resonance imaging,Cortical thickness,Longitudinal study,Negative symptoms

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