Updating the European Pharmacopoeia impurity profiling method for terazosin and suggesting alternative columns.

•A new (U)HPLC method was developed for terazosin impurity profiling to update the Ph. Eur. Method.•A generic workflow has been proposed to suggest replacement columns for a given separation.•Column comparison was based on the visualization and overlay of design spaces.•The new method was validated in accordance with international guidelines.