Design of a Novel Multi Epitope-Based Vaccine for Pandemic Coronavirus Disease (COVID-19) by Vaccinomics and Probable Prevention Strategy against Avenging Zoonotics

•A novel multi-epitope based chimeric vaccine is designed for coronavirus disease (COVID-19).•Nsp8, 3C-like proteinase, and spike glycoprotein are potential targets for immune responses to COVID-19.•Two epitopes: DRDAAMQRK and QARSEDKRA are predicted for Nsp8.•EDMLNPNYEDL and EFTPFDVVR epitopes are revealed for 3C-like proteinase.•Spike glycoprotein harbored one potential “VNNSYECDIPI” epitope.•A chimeric construct of the epitopes has high binding affinity for innate immune receptors.•Robust primary immune responses to the contrast are found.•The construct-immune receptors complexes are dynamically stable.•Vigorous molecular mechanics and solvation energy were observed in the complexes.