Rac1: A Potential Radiosensitization Target of Human Nasopharyngeal Carcinoma CNE2 Cells.

Chunmiao Wang,Zhaoquan Li,Zhiyu Pan,Zhengying Su,Wei Tian,Fu Lan,Dandan Liang,Junying Li,Danrong Li,Huaxin Hou

European Journal of Pharmaceutical Sciences（2020）

Cited 1|Views19

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Abstract

•Up-regulation of Rac1 can enhance the sensitivity of human poorly differentiated NPC CNE2 cells to radiation.•Oxidative damage of mitochondria induce by Rac1 may be a key mechanism of radiosensitization.•A new way for promoting the efficiency of radiotherapy by target regulation of Rac1 protein.

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Key words

Rac1,Radiosensitivity,Poorly differentiated nasopharyngeal carcinoma,Damage of mitochondria

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