Program and Abstracts Thirty-second Annual Meeting of the Surgical Infection Society Dallas, Texas April 18–21, 2012

Sean Whelan,Evie Carchman,Brian Zuckerbraun,Kareem Husain, Jason Keune,Bryan Sato,Steve Jarman, Yan Yan,William Carroll,Grant Bochicchio,Douglas Schuerer,John Mazuski,Alexander Zaborin, Alexander Polozov, Millicent Firestone,Olga Zaborina,John Alverdy, Mayank Taneja,James Purtill,Richard Rothman, Matt Austin, Javad Parvizi,Ibrahim Yazji,Sodhi Chhinder,Amin Afrazi,Misty Good,Matthew Neal,Hongpeng Jia,Joyce Lin,Maria Branca,Zachary Grant,Congrong Ma,Thomas Prindle,David Hackam,Heather Evans, Meliha Yetisgen-Yildiz, Cosmin Bejan,Keir Warner, Robert Black,Ronald Maier, Mark Wurfel,Carl Hauser, Tolha Sursal,Kiyoshi Itagaki,Shinichiro Kurosawa, Debby Stearns-Kurosawa,Claire Murphy, Joo Hyun Ha,Charles Cook,Kurt Stevenson,Chung Ho Leung, Feng Wang,Menachem Ailenberg,Brian Vadasz, Conrad Liles,Christopher Caldarone,Ori Rotstein,Benjamin Shogan,Andrea Olivas, William Trimble,Jack Gilbert,Olga Zaborina,John Alverdy,Aaron Heneghan,Joseph Pierre,Kenneth Kudsk,Pang Young,Barbara Pedrycz, Valerie Lucykx,Catharine Compston,Chris Lukowski,Thomas Mueller,Rachel Khadaroo,Weng-Lang Yang, Xialoing Qiang,Shingo Matsuo,Weifeng Dong,Jeffrey Nicastro,Gene Coppa, Ping Wang, Gina Howell,Richard Collage,Patricia Loughran,Xianghong Zhang,Matthew Rosengart,Stephen Gale,Susette Coyle,Steven Calvano,Siobhan Corbett,Stephen F Lowry,Jeremy Thompson,Matthew Eckert,Marcus Dortch,Jonathon Pouliot,Patrick Norris, Erik Boczko,Addison May, George DeBusk,Andrew Stephen,Sean Monaghan,Michael Connolly,Shea Gregg,Charles Adams, William Cioffi, Daithi Heffernan,Sandra Swoboda,Pamela Lipsett,Azra Bihorac,Tezcan Ozrazgat Baslanti,Alex Cuenca,Philip Efron,Ronald Maier,Lyle Moldawer,Vanessa Ho,Peter McWhorter, Jeffrey Johnson,Soumitra Eachempati,Jian Shou,Philip S Barie,Aman Banerjee, Katherine Kelly, Hannah Zhou, Shanteria Dixon,Jeffrey Claridge,Shannon Castle, Larry Wang,Anatoly Grishin,Henri Ford,Mark Frey,Ziad Kanaan,Rebecca Barnett,Sarah Gardner, Jim Peyton,William Cheadle,Benyam Yoseph,Elise Breed, Zhe Liang,Amy Fox, Dave O'Donnell, Michael Dunne,Kevin McConnell,Craig Coopersmith,Mary Ottinger,Sean Monaghan, Stefan Gravenstein,William Cioffi,Alfred Ayala,Daithi Heffernan,Nicole Lopez,Brian Eliceiri

Surgical Infections(2012)

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摘要
Background: Organ injury and dysfunction in sepsis accounts for significant morbidity and mortality. Adaptive cellular responses in the setting of sepsis prevent irreversible injury and allow for organ recovery. Others and we have shown that part of the adaptive response includes regulation of respiration and maintenance of a healthy mitochondrial population.Hypothesis: The purpose of these investigations were to test the hypothesis that regulation of mitochondrial respiration and homeostasis is regulated by inducible nitric oxide synthase (iNOS)/NO signaling. Furthermore, NO signaling is dependent on upregulation of heme oxygenase-1 (HO-1) and carbon monoxide (CO) signaling.Methods: Experimental sepsis was induced using a cecal ligation and puncture model in iNOS knockout (ko) or wild type (C57BL/6) mice. Some mice were randomized to treatment with CO-releasing molecule (CORM 10mg/kg), the NO …
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