Mechanistic modeling explains the dsRNA length-dependent activation of the RIG-I mediated immune response.

Darius Schweinoch, Pia Bachmann,Diana Clausznitzer,Marco Binder,Lars Kaderali

Journal of Theoretical Biology（2020）

引用 5|浏览9

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摘要

•RIG-I binds to internal positions on double-stranded RNAs (dsRNAs)•DsRNA length determines the sensitivity of RIG-I binding and immune signalling.•DsRNA length compensates for lack of high-affinity binding motifs.•The RIG-I binding mechanism allows discrimination between self- and non-self RNAs.

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关键词

ODE,Binding mechanism,Mathematical model,Antiviral response,pattern recognition receptor (PRR)

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