What intervention regimen is most effective prevention for Portal venous system thrombosis after splenectomy in cirrhotics patients with Portal hypertension? Systematic review and network meta-analysis

•PVST is a life-threatening complication after splenectomy in patients with portal hypertension, interventions may prevent the incidence.•While the most appropriate intervention regimen and application time for preventing the incidence of PVST is still uncertain.•The application of interventions was better than no intervention use, and early application of interventions was better.•Early application of low molecular weight heparin combined with low molecular dextran seems to be the most satisfactory treatment.