Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model
Journal of Affective Disorders(2020)
Abstract
•The levels of IL-6, IL-8, MCP-1 and VEGF were elevated in the serum of MDD patients and NOD macaca fascicularis.•The aLPS and cLPS depressed mice displayed higher serum concentrations of IL-6 and VEGF than these in control mice.•The prefrontal cortex of the LPS-treated mice showed increased expressions of IL-6 and VEGF.•The IL-6 and VEGF may as predictive biomarkers for novel diagnostic as well as therapeutic of depression.•The hypothalamus may as a key brain region involve in the inflammation related depressive-like behaviors.
MoreTranslated text
Key words
Major depression disorder,Cytokine,LPS,Inflammation,IL-6,VEGF
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined