Ultrasound supported synthesis of tantalum carbide integrated functionalized carbon composite for the voltammetric determination of the antibacterial drug nitrofurantoin in pharmaceutical samples
Microchimica Acta(2020)
摘要
The synthesis and fabrication of oval-shaped tantalum carbide (Ta-C) integrated functionalized-multiwalled carbon nanotube (Ta-C/f-MWCNT) as an electrocatalyst for the electrochemical determination of nitrofurantoin (NFT) is described. The Ta-C/f-MWCNT composite was prepared using the soft-template method followed by the ultrasonication process. The as-prepared Ta-C/f-MWCNT composite was characterized using powder X-ray diffraction (XRD), Raman spectroscopy, field emission scanning electron microscopy (FESEM), scanning transmission electron microscopy (STEM), and X-ray photoelectron spectroscopy (XPS) analysis. The electrochemical properties of Ta-C/f-MWCNT were investigated by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and linear sweep voltammetry (LSV). The Ta-C/f-MWCNT-modified glassy carbon electrode (Ta-C/f-MWCNT/GCE) was successfully utilized as an active electrocatalyst for the detection of NFT in the presence of 0.384 mM NFT containing 0.05 M phosphate buffer (pH 7) at a scan rate of 50 mV/s. The Ta-C/f-MWCNT/GCE exhibited a wide linear response range (0.04–1047 μM) and a low detection limit (0.0011 μM). Further, the Ta-C/f-MWCNT/GCE showed appreciable results for repeatability, reproducibility, and long-term cyclic stability towards NFT sensing. The Ta-C/f-MWCNT/GCE was applied to real sample analysis such as a commercial tablet and human urine samples. The Ta-C/f-MWCNT/GCE exhibited good recovery values for the tablet (105 to 115%) and urine (101–107%) samples. The above electrochemical results suggest that the Ta-C/f-MWCNT is a promising electrocatalyst for the electrochemical sensing of NFT drug. Graphical abstract .
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关键词
Metal carbide,Ta-C,Functionalized-MWCNT,Electrochemical sensor,NFT drug
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