Characterization of age-dependent behavior deficits in the PGC-1α knockout mouse, in relevance to the Parkinson's disease model.

•PGC-1α KO in mice induced general activity and motor impairment in 10-month-olds.•PGC-1α KO in mice induced bradykinesia in 20-month-olds.•PGC-1α KO in mice induced degeneration of dopaminergic neurons in 20-month-olds.•PGC-1α KO in mice induced DA deficits in the striatum of 10-month-olds.•PGC-1α KO in mice induced mitochondrial dysfunction in 10-month-olds.