Treatment effects may remain the same even when trial participants differed from the target population.
Journal of Clinical Epidemiology(2020)
摘要
Our RCT participants differed in composition to the wider population but the original findings were unaffected by sampling adjustments. We encourage investigators take steps to address criticisms of generalisability, but doing so is problematic: external data, even if available, may contain limited information and analyses can be susceptible to model misspecification.
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关键词
Randomized controlled trials,External validity,Generalizability,Sample reweighting
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