Klotho ameliorates the onset and progression of cataract via suppressing oxidative stress and inflammation in the lens in streptozotocin-induced diabetic rats
International Immunopharmacology(2020)
Abstract
•Klotho is decreased in plasma, aqueous humor and lens under diabetic conditions.•Klotho reduction enhances susceptibility to oxidative and inflammatory insults.•Klotho reduction promotes cataract formation under diabetic conditions.•Klotho treatment attenuates oxidative stress and inflammation in diabetic lens.•Klotho treatment ameliorate the onset and progression of diabetic cataract.
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Key words
Diabetic cataract,Klotho,Oxidative stress,Inflammation,Nuclear factor erythroid 2-related factor 2,Transcription factor NF-κB
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