Dual-responsive self-assembly in lysosomes enables cell cycle arrest for locking glioma cell growth.
CHEMICAL COMMUNICATIONS(2020)
Abstract
Herein we first report a dual-responsive peptide substrate (Comp. 1) for preparing self-assembled nanomaterials triggered by pH and legumain. The dual-responsive self-assembly ofComp. 1in glioma cells enables its long retention time in lysosomes, S phase arrest, and cell growth locking. We verified that the blocked degradation of HIF-1 alpha in lysosomes played a key role in cell cycle arrest and decreased DNA replication. This work illustrates the disturbance of lysosomal function by self-assembled nanomaterials as a promising strategy for inhibiting glioma cell growth.
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Key words
Self-Assembly
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