Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2.
Brain Research Bulletin(2020)
摘要
•EAAT2 expression in hippocampus reduced after H/R injury.•Midazolam alleviated H/R-induced apoptosis and learning and memory impairment.•Midazolam reversed the decreased expression of EAAT2 induced by H/R injury.•Involvement of EAAT2 in the neuroprotective effect of midazolam on H/R injury.
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关键词
EAAT2,hypoxia/reoxygenation,Midazolam,Excitotoxicity,Learning and memory,Astrocyte
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