Association between real-world experiential diversity and positive affect relates to hippocampal-striatal functional connectivity.

Greater novelty and diversity in one's daily physical environment is associated with positive affect, and functional connectivity within a hippocampal-striatal circuit is related to the strength of this effect. Experiential diversity promotes well-being in animal models. Here, using geolocation tracking, experience sampling and neuroimaging, we found that daily variability in physical location was associated with increased positive affect in humans. This effect was stronger for individuals who exhibited greater functional coupling of the hippocampus and striatum. These results link diversity in real-world daily experiences to fluctuations in positive affect and identify a hippocampal-striatal circuit associated with this bidirectional relationship.