Generation of a human induced pluripotent stem cell line, BRCi004-A, derived from a patient with age-related macular degeneration.

Kazuma Kamata,Yuki Otsuka,Keiko Imamura,Akio Oishi,Takayuki Kondo,Mika Suga,Ran Shibukawa,Yasue Okanishi,Yukako Sagara,Kayko Tsukita,Tsutomu Yasukawa, Hideaki Usui,Keiko Muguruma,Akitaka Tsujikawa,Haruhisa Inoue

Stem cell research（2020）

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Abstract

Age-related macular degeneration (AMD) is a late-onset progressive blinding disease. We established human induced pluripotent stem cells (iPSCs) from an AMD patient. The generated iPSC line showed pluripotency markers and three-germ layer differentiation ability in vitro. This iPSC line will be useful for elucidating the pathomechanisms of and drug discovery for AMD.

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