Effectiveness of deferiprone-loaded nanocarrier in experimentally induced rhabdomyolysis: A dose -comparison study
BIOORGANIC CHEMISTRY(2020)
摘要
•Nanogel co-polymer was prepared by gamma radiation-induced polymerization.•Rhabdomyolysis was induced in rats by receiving a single intra-muscular injection of glycerol.•Each of free DFP and nanogel-loaded DFP was orally administered following rhabdomyolysis induction.•Nanogel-loaded DFP was more effective in amelioration of the effects of rhabdomyolysis in liver, kidney and skeletal muscles.
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关键词
Rhabdomyolysis,Defriprone,Nanogel,Radiation-induced crosslinking
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