TGFβ1 alleviates axonal injury by regulating microglia/macrophages alternative activation in traumatic brain injury.

Junjie Zhao,Bo Wang,Xiang Wu,Zhongbo Yang,Tingqin Huang,Xiaoye Guo,Dan Guo,Zunwei Liu,Jinning Song

Brain Research Bulletin（2020）

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摘要

•We provided the important evidence of the protective role of TGFβ1 in the early stage of traumatic brain injury.•TGFβ1 interrupted neurotoxic cycle involved with microglia/macrophages after traumatic brain injury.•TGFβ1 promoted axonal recovery by regulating microglia/macrophages alternative activation after traumatic brain injury.

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关键词

TGFβ1,Traumatic brain injury,Axonal injury,Microglia/macrophages,Classical activation,Alternative activation

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