Is laparoscopic radical cholecystectomy an effective and safe approach for advanced gallbladder cancer?

Although laparoscopy has been widely used in the surgical field and is even considered the first-line to diagnose various diseases, laparoscopic radical cholecystectomy（LRC） for gallbladder cancer（GBC） has always been relatively contraindicated. Inadequate lymphadenectomy, complicated liver resection, specific biological behavior of GBC cells, and chimney and aerosol effects from the pneumoperitoneum are the previously misunderstood areas in laparoscopic surgery [1]. Initially, laparoscopic approach was used for intra-abdominal GBC exploration to determine the presence of peritoneal metastasis, intraoperative staging, and palliative