Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies.

Amy J Xu,Leo Luo,Jonathan E Leeman,Paul B Romesser,Daniel Spielsinger,Christopher Sabol,Todd Waldenberg,Thomas Brinkman,Nadeem Riaz,Sean McBride,Julie Kang,Nancy Lee,Chiaojung Jillian Tsai

Clinical and Translational Radiation Oncology（2020）

Cited 2|Views36

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Abstract

•Median local recurrence free survival after repeat reirradiation was 9.1 months.•Grade 4 toxicities were reported in 21% of patients.•61% of patients underwent subsequent therapies following repeat reirradiation.•Subsequent therapies following repeat reirradiation included surgery, chemotherapy and immunotherapy.•Repeat reirradiation is feasible and should be balanced against risk for toxicities.

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Key words

Salvage therapy,Reirradiation,Head and neck malignancies,Radiation toxicity

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