Structural and functional characterization of an organometallic ruthenium complex as a potential myorelaxant drug.

Biomedicine & Pharmacotherapy(2020)

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摘要
•The organoruthenium-nitrophen complex C1-Cl blocks skeletal muscle twitch.•The C1-Cl-induced twitch block is rapidly reversed by the ChE inhibitor neostigmine.•C1-Cl decreases the amplitude of muscle end-plate potentials.•C1-Cl has no effect on the resting membrane potential of muscle fibers.•C1-Cl may be considered as a potential myorelaxant drug.
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ACh,AChE,eeAChE,EtOH,C1-Cl,ChEs,EPPs,hrAChE,hsBChE,IC50,IQR,MEPPs,nH,nAChRs,nitrophen,PF6,rVm
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