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Persistence of the extinction of fear memory requires late-phase cAMP/PKA signaling in the infralimbic cortex.

Jeferson Machado Batista Sohn, Suzen Tortato Furtado de Souza,Ana Maria Raymundi,Jéssica Bonato,Rúbia Maria Weffort de Oliveira,Jos Prickaerts,Cristina Aparecida Jark Stern

Neurobiology of Learning and Memory（2020）

Cited 14|Views18
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Abstract
•Phosphodiesterase-4 inhibition 3 h after extinction improved the persistence of extinction.•Infralimbic cortex activity is associated with the effect of ROF on extinction.•cAMP-PKA activity in the IL is involved in the effect of ROF.•ROF treatment in the late phase of extinction consolidation enhances BDNF in IL.
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Key words
Fear conditioning,Phosphodiesterase,PTSD,BDNF,Roflumilast
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