Minimal alveolar concentration for deep sedation (MAC-DS) in intensive care unit patients sedated with sevoflurane: A physiological study.

Florian Blanchard,Sébastien Perbet,Arthur James, Frank Verdonck,Thomas Godet,Jean-Etienne Bazin,Bruno Pereira,Celine Lambert,Jean-Michel Constantin

Anaesthesia Critical Care & Pain Medicine（2020）

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摘要

In this physiological study involving 30 ICU patients, MAC-DS, end-tidal sevoflurane concentration to get 95% of patients in deep sedation determined over more than 500 observations, is achieved at 0.8% of expired fraction of sevoflurane or at 0.5 age-adjusted MAC.

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关键词

Sedation,Volatiles,Sevoflurane,Mechanical ventilation,ICU

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