Metabolomic Profiling In Patients With Metabolic Syndrome

Objective. To identify biomarkers, which are most specific for patients with metabolic syndrome (MS) using metabolomic profiling.Materials and Methods. Metabolomic profiling of patients with MS and comparison of their profile with the profile of volunteers was performed using high-performance liquid chromatography-mass-spectrometry.Results. The metabolomic profile of MS patients differed in several amino acids, including choline, cysteine, and serine and in the acylcarnitine group (р<0.05 for all comparisons).Conclusion. The metabolites most specific for MS patients were identified. Increased concentrations of a combination of amino acids and carnitines can be considered as possible additional risk factors for cardiovascular diseases.