The Protective Effects of 2'-Fucosyllactose against E. Coli O157 Infection Are Mediated by the Regulation of Gut Microbiota and the Inhibition of Pathogen Adhesion.
NUTRIENTS(2020)
摘要
As the richest component in human milk oligosaccharides (HMOs), 2'-fucosyllactose (2'-FL) can reduce the colonization of harmful microbiota in vivo, thus lowering the risk of infection; however, the mechanism for this is still unclear. In this study, a model ofEscherichia coliO157 infection in healthy adult mice was established to explore the effect of 2'-FL intervention onE. coliO157 colonization and its protective effects on mice. The results showed that 2'-FL intake reducedE. coliO157 colonization in mice intestine by more than 90% (p< 0.001), and it also reduced intestinal inflammation, increased the content of fecal short-chain fatty acids, and enhanced intestinal barrier function. These beneficial effects were attributed to the increased expression of mucins such asMUC2(increased by more than 20%,p< 0.001), and inhibition ofE. coliO157 cell adhesion (about 30% reduction,p< 0.001), and were associated with the modulation of gut microbiota composition. 2'-FL significantly increased the abundance ofAkkermansia, a potential probiotic, which may represent the fundamental means by which 2'-FL enhances the expression of mucin and reduces the colonization of harmful bacteria. The current study may support the use of 2'-FL in the prevention of foodborne pathogen infections in human.
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关键词
2 '-fucosyllactose,E.coli O157,reduced colonization,gut microbiota,Akkermansia
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