Cost Analysis of Treatment Strategies for the Control of HSV-2 Infection in the U.S.: A Mathematical Modeling-Based Case Study.

•The prevalence of Herpes continues to increase in spite of existing programs and hence, improved public health efforts are urgently needed.•Both, mild (constitutional) or severely (nonconstitutional) infected contribute to the transmission and so, both needs consideration.•Current treatment strategies only target individuals at the nonconstitutional stage, and miss mild cases, which are hard to detect and treat.•The proposed strategy of this study consists of treating patients in both stages and resulted in reduction of the incidence of Herpes by 38%.•The proposed strategy cost less and decreases R0 by 40% and hence, it has much higher potential for eliminating disease.