Pathogenic insights to Parkin-linked model mice

Shigeto Sato,Sachiko Noda,Nobutaka Hattori

Neuroscience Research（2020）

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摘要

•Atg7−/− mice show age-related motor dysfunction, Lewy pathology, and DA neuron loss.•Mitochondrial fragmentation was facilitated in DA neurons of aged Parkin-KO mice.•Impaired autophagy and mitochondrial clearance may underlie the pathology of PD.

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关键词

PD,AR PD,DA,LBs,TH,SN,VTA,SNcc,SNcl,HPLC

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