TAOK1 positively regulates TLR4-induced inflammatory responses by promoting ERK1/2 activation in macrophages.
Molecular Immunology(2020)
Abstract
•TAOK1increases TLR4-induced cytokine production in macrophages;•Decreased systemic inflammatory responses in TAOK1 deficient mice;•TAOK1 interacts with TRAF6 and TPL2 and then promotes TLR4-triggered ERK1/2 activation.
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Key words
TAOK1,TLRs,LPS,TRAF6,IL-6
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