Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design.

Qian Liu,Jin-Ping Liu,Jia-Hui Mei,Shuang-Jun Li,Li-Qiao Shi, Zong-Hao Lin, Bai-Yan Xie,Wei-Guang Sun,Zhen-Yu Wang,Xi-Liang Yang,Yu Zou,Wei Fang

Bioorganic & Medicinal Chemistry Letters（2020）

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摘要

•Ten compounds including betulin were isolated from P. incarnata and elucidated.•Betulin suppressed LPS-induced activation by inhibiting inflammatory cytokines.•Molecular docking suggested possible anti-inflammatory mechanism of betulin.•Betulin reduced iNOS expression, prevented JNKs and phosphorylation of NF-κB/p65.

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关键词

P. incarnata,LPS,NO,TNF-α,IL-6,IL-1β,NF-κB p65,IκB-α,JNKs,CNS,ELISA,DAPI,ANOVA,GPCRs

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