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Synthesis and Structure-Activity Relationships of Thieno[2,3-D]pyrimidines As Atypical Protein Kinase C Inhibitors to Control Retinal Vascular Permeability and Cytokine-Induced Edema.

Bioorganic & Medicinal Chemistry(2020)

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Key words
Blinding eye diseases,atypical protein kinaseC (aPKC),Vascular permeability,Vascular endothelial growth factor (VEGF),Tumor necrosis factor-alpha (TNF alpha),Homology model,Thieno[2,3-d]pyrimidine inhibitors,SAR
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