S-Nitroso-N-Pivaloyl-D-Penicillamine, a novel non-neuronal ACh system activator, modulates cardiac diastolic function to increase cardiac performance under pathophysiological conditions

Shino Oikawa,Yuko Kai,Asuka Mano,Shigeo Nakamura,Yoshihiko Kakinuma

International Immunopharmacology（2020）

Cited 3|Views4

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Abstract

•SNPiP improves cardiac function with increasing the diastolic function.•SNPiP more efficiently increases diastolic function of the heart than SNAP.•SNPiP improves impaired cardiac diastolic function of db/db mice.

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Key words

Acetylcholine (ACh),The non-neuronal ACh system in the heart,The non-neuronal cardiac cholinergic system (NNCCS),Cardiac diastolic function,Db/db mice

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