Weight Change 2 Years After Termination Of The Intensive Lifestyle Intervention In The Look Ahead Study

OBESITY(2020)

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摘要
Objective This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group.Methods Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012.Results Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean (SE) of 1.2 (0.2) kg and 1.8 (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained >= 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost >= 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants.Conclusions Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained >= 2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.
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