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Long-chain non-coding RNA HOTAIR promotes the progression of osteoarthritis via sponging miR-20b/PTEN axis.

Yingchun Chen,Lin Zhang,Ernan Li,Genai Zhang,Yu Hou,Wei Yuan,Qu Wei,Lixiang Ding

Life Sciences（2020）

Cited 37|Views14
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Abstract
HOTAIR can participate in OA by promoting chondrocyte apoptosis and ECM degradation, which may be related to its targeted regulation of miR-20b/PTEN axis.
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Key words
Osteoarthritis,HOX transcript antisense intergenic RNA,miR-20b,Phosphatase and tension homolog deleted from chromosome 10,Extracellular matrix degradation
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